MeanWilliamsDesign.Equivalence {TrialSize} | R Documentation |
Compare more than two treatment under a crossover design.
H0: |margin| ≥ δ Ha: |margin| < δ
This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha
MeanWilliamsDesign.Equivalence(alpha, beta, sigma, k, delta, margin)
alpha |
significance level |
beta |
power = 1-beta |
sigma |
standard deviation |
k |
Total k treatments in the design |
delta |
the superiority or non-inferiority margin |
margin |
margin=μ_i-μ_j the difference between the true mean response of group i μ_i and group j μ_j |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003