OneSampleMean.NIS {TrialSize} | R Documentation |
Ho: margin ≤ delta Ha: margin > delta
if delta >0, the rejection of Null Hypothesis indicates the true mean is superior over the reference value mu0;
if delta <0, the rejection of the null hypothesis implies the true mean is non-inferior against the reference value mu0.
OneSampleMean.NIS(alpha, beta, sigma, margin, delta)
alpha |
significance level |
beta |
power = 1-beta |
sigma |
standard deviation |
delta |
the superiority or non-inferiority margin |
margin |
margin=\bar{x}-μ_0 the difference between the true mean response of a test \bar{x} and a reference value μ_0 |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
Example.3.1.4<-OneSampleMean.NIS(0.05,0.2,1,0.5,-0.5) Example.3.1.4 # 7