Cochran.Armitage.Trend {TrialSize} | R Documentation |
H0: p0=p1=p2=...=pK
Ha: p0 <= p1 <= p2 <=...<= pK with p0 < pK
Cochran.Armitage.Trend(alpha, beta, pi, di, ni, delta)
alpha |
significance level |
beta |
power = 1-beta |
pi |
pi is the response rate in ith group. |
di |
di is the dose level |
ni |
ni is the sample size for group i |
delta |
delta is the clinically meaningful minimal difference |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
pi=c(0.1,0.3,0.5,0.7); di=c(1,2,3,4); ni=c(10,10,10,10); Example.11.5<-Cochran.Armitage.Trend(alpha=0.05,beta=0.2,pi=pi,di=di,ni=ni,delta=1) Example.11.5 # 7.5 for one group. Total 28-32.