DFDR.p.adjust {MHTmult} | R Documentation |
Given a list/data frame of grouped p-values, retruns adjusted p-values to make decisions
DFDR.p.adjust(pval, t, make.decision, alpha)
pval |
the structural p-values, the type should be |
t |
the threshold selecting significant families. |
make.decision |
logical; if |
alpha |
significant level used to compare with adjusted p-values to make decisions, the default value is 0.05. |
A list of the adjusted p-values, a list of NULL
means the family is not selected to do the test in the second stage.
Yalin Zhu
Mehrotra, D. V., & Heyse, J. F. (2004). Use of the false discovery rate for evaluating clinical safety data. Statistical methods in medical research, 13: 227-238.
# data is from Example 4.1 in Mehrotra and Adewale (2012) pval <- list(c(0.031,0.023,0.029,0.005,0.031,0.000,0.874,0.399,0.293,0.077), c(0.216,0.843,0.864), c(1,0.878,0.766,0.598,0.011,0.864), c(0.889,0.557,0.767,0.009,0.644), c(1,0.583,0.147,0.789,0.217,1,0.02,0.784,0.579,0.439), c(0.898,0.619,0.193,0.806,0.611,0.526,0.702,0.196)) DFDR.p.adjust(pval = pval,t=0.1) sum(unlist(DFDR.p.adjust(pval = pval,t=0.1))<=0.1)