ReturnMeanControl {Phase123} | R Documentation |
Returns the mean survival times for the control given efficacy and toxicity dose probability vector, distribution family and linear relationship, effiacy, toxicity and survival.
ReturnMeanControl(ProbC, betaC, Family, alpha)
ProbC |
Probability of efficacy and toxicity for the control therapy. |
betaC |
Linear term for efficacy, toxicity and beta_0 for the control groupar term for efficacy, toxicity and beta_0 for the control group. |
Family |
Time to event distribution. Options include: Exponential, Gamma, Weibull, Lognormal. |
alpha |
Shape parameter or standard deviation of a lognormal distribution. |
[1] Chapple and Thall (2018).A Hybrid Phase I-II/III Clinical Trial Design Allowing Dose Re-Optimization in Phase III. Biometrics. In Press,
###Family of Distributions Family="Gamma" ###Shape parameter alpha=2 ##True beta vector for efficacy, toxicity and intercept of the control treatment betaC=c(.3,-.25,2.389) ##True efficacy and toxicity probability for control group ProbC = c(.4,.15) ReturnMeanControl(ProbC,betaC,Family,alpha)