instaIndex {Peptides} | R Documentation |
This function calculates the instability index proposed by Guruprasad (1990). This index predicts the stability of a protein based on its amino acid composition, a protein whose instability index is smaller than 40 is predicted as stable, a value above 40 predicts that the protein may be unstable.
instaIndex(seq)
seq |
An amino-acids sequence |
The computed instability index for a given amino-acids sequence
Guruprasad K, Reddy BV, Pandit MW (1990). "Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence". Protein Eng. 4 (2): 155 - 61. doi:10.1093/protein/4.2.155
# COMPARED TO ExPASy INSTAINDEX # http://web.expasy.org/protparam/ # SEQUENCE: QWGRRCCGWGPGRRYCVRWC # The instability index (II) is computed to be 83.68 instaIndex(seq = "QWGRRCCGWGPGRRYCVRWC") # [1] 83.68